When 11-year-old Riley moves to a new city, her Emotions team up to help her through the transition. Joy, Fear, Anger, Disgust and Sadness work together, but when Joy and Sadness get lost, they must journey through unfamiliar places to get back home.

Teenage Riley's head is turned upside down when new emotions appear during a particularly trying time in her life. Joy, Sadness, Anger, Fear and Disgust, who've long been running a successful operation by this point, aren't sure how to feel about these new emotions showing up in Headquarters.

Riley is growing up and when her memories need some extra processing, Joy and the rest of the Core Emotions send them to Dream Productions. Acclaimed director Paula Persimmon faces a nightmare of her own: trying to create the next hit dream after being paired up with Xeni, a smug daydream director looking to step up into the big leagues of night dreams.